Culture Shock: Web-Based Hep C Tx Guidelines

Practice guidelines are a fact of life in modern medicine. They provide clinicians with the best data and the latest consensus on what the data mean for the care of patients.

But they are — or have been — rather slow to react to changes.

Enter HCVguidelines.org, a website that aims to keep up with one of the fastest-moving fields in medicine today — the treatment of hepatitis C virus (HCV) with what are called direct-acting agents.

The website was developed and will be run jointly by the American Association for the Study of Liver Diseases, the Infectious Diseases Society of America, and the International Antiviral Society-USA.

Read more at MedPage Today

Study Dispels “Obesity Paradox” in Diabetes

A study in the New England Journal of Medicine finds no evidence of a so-called “obesity paradox” in type 2 diabetes — that is, the suggestion that mortality is lower among diabetics who are overweight or obese than among those who are normal weight.

Researchers studied over 11,000 healthcare professionals who were free of cardiovascular disease or cancer at the time of diabetes diagnosis. During 16 years’ follow-up, roughly 3000 participants died.

Overall, the association between baseline BMI and all-cause mortality was J-shaped: Compared with normal-weight participants, underweight participants and those with BMIs of 30 or above had significantly increased mortality risks, with the highest risk at BMIs of 35 or higher (hazard ratio, 1.33).

Previous studies that suggested an obesity paradox were limited by short follow-ups and few deaths, the authors write. They conclude that maintaining a healthy weight “should remain the cornerstone of diabetes management.”

– See more at: http://www.nejm.org/doi/full/10.1056/NEJMoa1304501

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