Imaging Sign of the Day: Tree in Bud Sign

Tree in bud sign – describes the CT chest appearance of multiple centrilobular nodules that are connected by branching opacified bronchioles. Although initially described in patients with endobronchial tuberculosis, it is now recognized in a large number of conditions ranging from small airways infections like mycobacterium avium complex, to connective tissue diseases like rheumatoid arthritis, to neoplastic conditions like bronchioloalveolar cell carcinoma.

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